Comprehensive coverage

Adding a molecule synthesized from broccoli to the toothpaste will help prevent bacteria

An international group of scientists, including researchers from Ben Gurion University, suggest adding a natural molecule that will significantly reduce biological infections in the oral cavity.

The majority of the world's population chronically suffers from a layer of bacteria on the teeth (plaque) that creates caries that eventually causes cavities and deterioration in oral hygiene. Toothpastes, mouthwashes and treatment by a dentist are effective to some extent, but scientists from Ben-Gurion University of the Negev, Sichuan University and the National University of Singapore suggest adding a natural molecule that will significantly reduce biological infections in the oral cavity. The research findings were published in the journal Antibiotics.

Our mouth is a great breeding ground for bacteria that grow in the oral cavity where there is a supply of food (sugars) and moist conditions. The interaction between bacteria in the oral cavity is complex and involves competition for space and nutrients. Due to high microbial loads in a relatively small place, the combination of various types of bacteria, fungi and viruses allow the creation of chronic infections in the oral cavity.

Streptococcus mutans (Streptococcus mutans) is one of the important bacteria present in the biofilm, a colony of bacteria that coats the teeth. It attacks the enamel on the tooth and eventually causes cavities. The infections associated with biofilm are difficult to treat due to repeated infections and resistance to disinfectants and antibiotics.

Prof. Ariel Kushmaro, the director of the Laboratory for Environmental Biotechnology at Ben-Gurion University of the Negev, together with his research group and his colleagues from Sichuan University and the National University of Singapore, discovered that a natural molecule (Diindolylmethane -DIM) also known as bis-indole (DIM), reduces the ability of the bacterium Streptococcus to create 90% biofilm, so the bacterium is not given a chance to establish itself.

The researchers made an observation of the microbial diversity and understanding the nature of the interactions, and noticed that the structure of the molecule is similar to other active molecules found in the marine environment that harm the creation of a biofilm and have the structure of two rings of indole (bis-indole). The DIM molecule originates from certain plants of the cruciferous family (such as broccoli) and when it is used in its synthesized form, it has been noticed that it succeeds in eradicating the ability to form a biofilm even in the bacteria that cause tooth decay. The molecule is also known to be anti-cancer at higher concentrations, so it is a substance that has been tried in various clinical studies in the past. If so, it seems that there is a possible solution to tooth decay and it is even natural.

"Targeted damage to violent factors, including biofilm, is a targeted treatment that does not create selection pressure similar to the activity of antibiotics," she said Dr. Karina Gulberg, the research partner.

"The research indicates that it is possible to add to toothpastes and mouthwashes the molecule that will help and greatly improve oral and dental hygiene. The data indicate a high efficiency in protecting against the creation of a biofilm by the bacteria that causes caries, so that in the future we will be able to protect the teeth in a better and more efficient way", concluded the chief researcher Prof. Ariel Kushmaro.

The research group included: Yifat Baruch, Dr. Karina Golberg, and Prof. Robert S. Marx from the Department of Biotechnology Engineering at Ben-Gurion University of the Negev, Kwon Sun from Sichuan University, and Karina Yu-Hong Jin from the National University of Singapore.

The study was supported by the Sichuan International Research and Development Program (2019YFH0113) and the Singapore Innovation Grant (SMARTING-000398 (.

One response

  1. Before causing (any more) revolutions in oral hygiene, you should also check and make sure that the new substance is not harmful to the population of good bacteria in the mouth:

    https://www.drzivav.com/2023/08/14/oralbacteria/

    And in general consume less processed products, and animal products, and equip yourself with a good electric toothbrush.

Leave a Reply

Email will not be published. Required fields are marked *

This site uses Akismat to prevent spam messages. Click here to learn how your response data is processed.