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Researchers have discovered a mechanism of heart tissue regeneration

Researchers from the Weizmann Institute found that the biological processes associated with aging, it turns out, also do the opposite and help the regeneration of heart tissue * The study emphasizes the need to be careful when using drugs that aim to get rid of aging cells, especially during healing processes. It was found that the use of such drugs can harm the healing process of the heart

How the "aging" mechanism called senescence is activated for a short time after an injury to the heart of mice as an essential part of the heart's healing process. Courtesy of the researchers
How the "aging" mechanism called senescence is activated for a short time after an injury to the heart of mice as an essential part of the heart's healing process. Courtesy of the researchers

Biological processes associated with aging are essential for heart tissue regeneration. This surprising conclusion emerges from a study published in the scientific journal Nature Cardiovascular Research.

Behind the research is a team led by Dr. Rachel Sarig and research student Lingling Chang from Prof. Eldad Tzhor's laboratory at the Weizmann Institute of Science - a world leader in the field of heart regeneration and healing research.

In the study, the scientists reveal in unprecedented detail - at the single cell level - how the "aging" mechanism called senescence is activated for a short time after an injury to the heart of mice as an essential part of the heart's healing process. This study joins a series of studies from recent years that show the essential roles of this mechanism in the processes of development and regeneration of tissues, so caution must be taken when trying to "get rid" of these cells using drugs - a research and treatment approach that is prevalent today and may turn out to be dangerous.

The role of senescent cells in the healing process

The aging cells are cells that stop dividing and begin to secrete various substances that affect their environment. This process happens in response to various stresses such as DNA damage or environmental stress. Although the term "senescent cells" is often associated with aging and diseases such as cancer, recent studies reveal their central role in healing and regeneration processes.

In the new study, the team at the Weizmann Institute used advanced techniques such as proteomics and single-cell RNA sequencing (scRNA-seq) to examine the changes that occur in heart cells after injury. They discovered that fibroblast cells in the heart enter a temporary senescence state, where they stop dividing but begin to secrete substances that promote tissue healing, such as angiogenesis (the creation of new blood vessels), and the breakdown of the extracellular matrix.

The mechanism of aging in the heart

The fibroblast cells that enter a senescent state are mainly active through signal pathways such as MAPK-ERK, NFκB and TGFβ, which encourage the healing process. One of the key findings of the study was the identification of the transcription factor Egr1 as an important regulator of regenerative aging. Egr1 affects many cellular processes in the heart, and its activation has also been found in the hearts of children and young adults, suggesting its essential role in cardiac regeneration.

Clinical implications

The study highlights the need to be careful when using drugs aimed at getting rid of aging cells, especially during healing processes. It was found that the use of such drugs can harm the healing process of the heart.

In addition, the study indicates the importance of identifying the specific components of the SASP (senescence-associated secretory phenotype) found in the fibroblast cells. Understanding these components can help in the development of innovative treatments aimed at encouraging the healing process without damaging the vital cells.

The study opens doors for future studies that will examine the differences between regenerative aging cells and those in disease and aging models. Understanding the dynamics of the SASP and its effect on the healing process may lead to the development of treatments that utilize this process in a controlled manner.

In addition, the study highlights the need to continue investigating the role of Egr1 in the healing and regeneration processes of the heart, especially in humans. These results can help in the development of personalized treatments based on the activation of natural biological pathways.

Comments

  1. The question is, which drugs are the ones to be careful with. On the other hand, while mice are mammals, laboratory animals are not human beings. Have they done experiments on humans? The Helsinki Committee is needed for such a purpose. We are not China or North Korea...

  2. And now that they have found this research, the health organization in every country in the world will work to check what vaccines and what crap can be concocted and given to a person to stop this regeneration so that people will continue to buy drugs and continue to be enslaved to their desires for shit and their greed for money, scoundrels

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